New Delhi: A brand new take a look at has raised worries about the function of collagen inside the progression of type 2 diabetes, suggesting it could worsen the sickness through growing the toxicity of positive hormones inside the pancreas. Conducted by researchers from IIT Bombay, IIT Kanpur, and the Chittaranjan national cancer Institute in Kolkata, the take a look at exhibits how a key structural protein inside the frame, collagen I, may additionally contribute to the harm of insulin-producing cells.

Type 2 diabetes, a circumstance characterized via extended blood sugar stages, typically arises from an aggregate of genetic, way of life, and biological elements. In this circumstance, the body either doesn’t produce enough insulin or turns resistant to it. Along with insulin, the pancreas additionally produces every other hormone, amylin, which allows adjusting blood sugar after food.However, in humans with type 2 diabetes, extended demand for insulin also results in an upward thrust in amylin stages.

In contrast to insulin, amylin is liable to misfolding, changing shape in a damaging way, specifically whilst found in high concentrations. Those misfolded amylin molecules generally tend to clump together, forming poisonous aggregates that may damage mobile membranes, block nutrient glide, and sooner or later result in cell dying. till now, it wasn’t clear what caused this dangerous clumping in diabetic tissues.

They have a look at identifying collagen I, a major aspect of the extracellular matrix (the structural framework round cells), as a critical trigger. Consistent with Professor Shamik Sen of IIT Bombay, who led the study, collagen I becomes more abundant in diabetic pancreatic tissue. This excess collagen acts as a scaffold that hurries up amylin aggregation, making it more poisonous and contributing to the destruction of β-cells, the cells accountable for producing insulin.

This β-mobile harm further weakens the frame’s ability to regulate blood sugar, pushing individuals towards severe or complete-blown diabetes. Published inside the journal of the yank Chemical Society, the take a look at sheds mild on a formerly ignored thing of diabetes: the role of the extracellular matrix, and the way its interplay with hormones like amylin ought to pressure disease progression.

Professor Sen emphasizes that this discovery could assist provide an explanation for why a few remedies focusing entirely on mobile techniques have limited fulfillment. “Until we disrupt the interplay among amylin and collagen, we may not be able to absolutely get rid of the toxic environment in the pancreas,” he stated.

The findings open new avenues for research and remedy, suggesting that focused on the extracellular matrix, and particularly collagen I, ought to emerge as a crucial method in dealing with or slowing the progression of type 2 diabetes.

Sources https://www.indiatvnews.com/health/is-collagen-bad-for-type-2-diabetes-new-research-suggests-potential-health-risks-2025-07-07-997728

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