New Delhi, May 5 (IANS) – Molecular profiling can substantially lessen the want for radiotherapy in girls with early-level endometrial cancer, at the same time as identifying people who might benefit from more extensive treatment, in keeping with a new look at advancing personalized cancer care.

Endometrial most cancers, a commonplace gynaecological malignancy affecting specifically postmenopausal women, is regularly handled with surgical treatment accompanied by means of adjuvant radiotherapy, specifically vaginal brachytherapy, to decrease the threat of recurrence in high-intermediate- hazard instances.

But, no longer all sufferers require the same level of remedy, and lots may additionally go through needless radiotherapy, exposing them to avoidable side effects.The take a look at, offered at the ESTRO 2025 congress in Vienna, Austria, involved 592 women across 8 European international locations. It discovered that the usage of molecular profiling, which examines the genetic and biological traits of tumours, can properly personalise radiotherapy choices.

“By means of the usage of molecular profiling, we are able to tailor remedies to each affected person’s individual hazard,” stated lead investigator Dr. Anne Sophie V.M. van den Heerik from Leiden university scientific center, Netherlands. “This lets us lessen radiation publicity for plenty of ladies whilst making sure the pleasant possible therapy for folks who need it.

”The findings confirmed that almost half the patients were capable of safely avoiding radiation without compromising most cancers. In the meantime, people with excessive- hazard molecular profiles acquired intensified pelvic radiotherapy, resulting in a substantially decreased recurrence fee (8.4%) in comparison to the ones receiving fashionable remedies without profiling (30.5%).

The outcomes underline the potential of molecular profiling to improve consequences and reduce overtreatment in endometrial most cancers.

Sourceshttps://www.lokmattimes.com/technology/molecular-profiling-key-to-reduce-radiation-for-women-with-endometrial-cancer-study-1/#:~:text=endometrial%20cancer%3A%20Study-,New%20Delhi%2C%20May%205%20Molecular%20profiling%20can%20safely%20reduce%20radiotherapy,forward%20in%20personalised%20cancer%20treatment.

Molecular profiling key to reduce radiation for women with endometrial cancer: Study