New Delhi: a team of American researchers has decoded that genetic and lifestyle factors can determine why certain people with Down syndrome suffer from dementia.

Studies reveal that people with Down syndrome have more than a life risk of 90 to develop dementia caused by Alzheimer’s disease as they age. However, the link behind the conditions was not yet known.

Alzheimer’s is the most common cause of dementia. People with Down syndrome were born with an additional copy of chromosome 21, which affects how their brain and their body develop.

Alzheimer’s is a progressive brain disorder that slowly destroys the search for memory and the skills in thought of the universities of Pittsburgh and California has found an unexpected progression of Alzheimer’s disease in a woman with syndrome.

The patient with Down syndrome participated in the study for 10 long years and donated her brain for research after her death. “We are interested in trying to connect neuroimagery with neuropathology, because we want to use information from neuropathology data games to clarify the diagnostic and therapeutic criteria for people with Down syndrome before dying,” said Jr-Jiun Liou, a postdoctoral scholar in the department of Bio-Sectionnian, University of Pittsburgh, who imagined his brain using a high resolution screen.

Although the woman was stable cognitive at the time of death, MRI imagery revealed the presence of neuropathology indicating Alzheimer’s disease in her brain. “Before her death, all the clinical assessments of our year’s study indicated that she was a stable cognitive, which is why this affair is so fascinating,” said Liou.

“Despite the pathology of his brain indicating Alzheimer’s disease, we believe that its cognitive stability could have been attributed to its high level of teaching or to underlying genetic factors.” “This is a way that affects your memory and is directly involved in human Alzheimer’s disease,” said Lipton.

In the Alzheimer’s model and in human neurons derived from stem cells of neurodegenerative state patients, the team observed high levels of S-Nitrosyl CRTC1 at an early stage of the disease. The results also support the idea that chemical change plays a key role in developing the symptoms of the disease.

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Genetic, lifestyle factors may explain why Down syndrome leads to dementia: Study

https://morungexpress.com/genetic-lifestyle-factors-may-explain-why-down-syndrome-leads-to-dementia-study